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《医学前沿(英文)》 2015年 第9卷 第4期 页码 478-486 doi: 10.1007/s11684-015-0420-0
Telomeres play a critical role in biological ageing by maintaining chromosomal integrity and preventing chromosome ends fusion. Epidemiological studies have suggested that inter-individual differences of telomere length could affect predisposition to multiple cancers, but evidence regarding esophageal squamous cell carcinoma (ESCC) was still uncertain. Several telomere length-related single nucleotide polymorphisms (TL-SNPs) in Caucasians have been reported in genome-wide association studies. However, the effects of telomere length and TL-SNPs on ESCC development are unclear. Therefore, we conducted a case-control study (1045 ESCC cases and 1433 controls) to evaluate the associations between telomere length, TL-SNPs, and ESCC risk in Chinese population. As a result, ESCC cases showed overall shorter relative telomere length (RTL) (median: 1.34) than controls (median: 1.50, P<0.001). More interestingly, an evident nonlinear U-shaped association was observed between RTL and ESCC risk (P<0.001), with odds ratios (95% confidence interval) equal to 2.40 (1.84–3.14), 1.36 (1.03–1.79), 1.01 (0.76–1.35), and 1.37 (1.03–1.82) for individuals in the 1st (the shortest), 2nd, 3rd, and 5th (the longest) quintile, respectively, compared with those in the 4th quintile as reference group. No significant associations were observed between the eight reported TL-SNPs and ESCC susceptibility. These findings suggest that either short or extremely long telomeres may be risk factors for ESCC in the Chinese population.
关键词: esophageal squamous cell carcinoma telomere length genetic variants susceptibility genome-wide association study
Li-Feng LIU MD, PhD, Qiong CHEN MD, PhD, Ying CHANG MD, PhD, Ju-Sheng LIN MD, PhD, Jin-Liang ZHANG MM,
《医学前沿(英文)》 2010年 第4卷 第1期 页码 90-95 doi: 10.1007/s11684-010-0021-x
关键词: cyclooxygenase-2 gene single nucleotide polymorphisms susceptibility primary hepatocellular carcinoma hepatitis B virus infection
林元,陈小玲,林晓文,刘敏,徐两蒲,何德钦,高丽素
《中国工程科学》 2014年 第16卷 第5期 页码 73-78
采用以院为基础的病例对照研究,在福建省妇幼保健院(三级甲等医院)募集新近发生的69 例胎儿先天性心脏病病例,以1∶1 配对的方法设立对照组,采用电感耦合等离子体质谱仪分析方法,测定病例组和对照组孕妇孕期头发中锑、锌、铜、铁、铅等元素的含量,并问卷调查孕早期危险因素的暴露情况,用SPSS19.0 Cox 比例风险模型进行流行病学多因素分析。孕妇发锑含量偏高(相对危险度的比值比(OR) =33.833;95 %可信区间(CI):4.060~281.929)、孕期使用不锈钢餐具(OR=8.981,95 % CI:1.085~74.327)、居所周围50 m有马路(OR=11.067,95 % CI:1.025~119.521)是先天性心脏病的危险因素。孕期锑负荷增加可能是先天性心脏病的原因之一。
《医学前沿(英文)》 2021年 第15卷 第3期 页码 438-447 doi: 10.1007/s11684-020-0826-1
关键词: sporadic thoracic aortic dissection exome sequencing gene COL3A1 case–control study extracellular matrix
Alcohol and tea consumption in relation to the risk of nasopharyngeal carcinoma in Guangdong, China
Hong-Lian RUAN, Feng-Hua XU, Wen-Sheng LIU, Qi-Sheng FENG, Li-Zhen CHEN, Yi-Xin ZENG, Wei-Hua JIA,
《医学前沿(英文)》 2010年 第4卷 第4期 页码 448-456 doi: 10.1007/s11684-010-0280-6
关键词: nasopharyngeal carcinoma case-control study alcohol consumption tea consumption
EXPLORING THE RECYCLING OF MANURE FROM URBAN LIVESTOCK FARMS: A CASE STUDY IN ETHIOPIA
《农业科学与工程前沿(英文)》 2021年 第8卷 第1期
• Livestock manure was the main organic waste in urban and peri-urban areas.
• Manure production will increase by a factor of 3–10 between 2015–2050.
• Only 13%–38% of excreted N by livestock will be recycled in croplands.
• Intensification of urban livestock production greatly increased N surpluses.
• Reducing population growth and increasing livestock productivity needed.
Urban population growth is driving the expansion of urban and peri-urban agriculture (UPA) in developing countries. UPA is providing nutritious food to residents but the manures produced by UPA livestock farms and other wastes are not properly recycled. This paper explores the effects of four scenarios: (1) a reference scenario (business as usual), (2) increased urbanization, (3) UPA intensification, and (4) improved technology, on food-protein self-sufficiency, manure nitrogen (N) recycling and balances for four different zones in a small city (Jimma) in Ethiopia during the period 2015-2050. An N mass flow model with data from farm surveys, field experiments and literature was used. A field experiment was conducted and N use efficiency and N fertilizer replacement values differed among the five types of composts derived from urban livestock manures and kitchen wastes. The N use efficiency and N fertilizer replacement values were used in the N mass flow model.
Livestock manures were the main organic wastes in urban areas, although only 20 to 40% of animal-sourced food consumed was produced in UPA, and only 14 to 19% of protein intake by residents was animal-based. Scenarios indicate that manure production in UPA will increase 3 to 10 times between 2015 and 2050, depending on urbanization and UPA intensification. Only 13 to 38% of manure N will be recycled in croplands. Farm-gate N balances of UPA livestock farms will increase to>1 t·ha−1 in 2050. Doubling livestock productivity and feed protein conversion to animal-sourced food will roughly halve manure N production.
Costs of waste recycling were high and indicate the need for government incentives. Results of these senarios are wake-up calls for all stakeholders and indicate alternative pathways.
FULL TIME-SPACE GOVERNANCE STRATEGY AND TECHNOLOGY FOR CROPLAND NON-POINT POLLUTION CONTROL IN CHINA
《农业科学与工程前沿(英文)》 2023年 第10卷 第4期 页码 593-606 doi: 10.15302/J-FASE-2023522
Ensuring food safety while reducing agricultural non-point source pollution is quite challenging, especially in developing and underdeveloped countries. Effective systematic strategies and comprehensive technologies need to be developed for agricultural non-point source pollution control at the watershed scale to improve surface water quality. In this review, a proposal is made for a full time-space governance strategy that prioritizes source management followed by endpoint water pollution control. The 4R chain technology system is specifically reviewed, including source reduction, process retention, nutrient reuse and water restoration. The 4R chain technology system with the full time-space governance strategy was applied at the scale of an administrative village and proved to be a feasible solution for reducing agricultural non-point source pollution in China. In the future, a monitoring system needs to be established to trace N and P transport. Additionally, new smart fertilizer and intelligent equipment need to be developed, and relevant governance standards and supportive policies need to be set to enhance the efficacy of agricultural non-point source pollution control.
关键词: 4R chain technology system agricultural non-point source pollution case study full time-space governance strategy
Microplastics in municipal wastewater treatment plants: a case study of Denizli/Turkey
《环境科学与工程前沿(英文)》 2023年 第17卷 第8期 doi: 10.1007/s11783-023-1699-8
● High amounts of microplastics are released to receiving media from WWTPs.
关键词: Microplastics Wastewater treatment plant Removal efficiency Daily discharge
《工程管理前沿(英文)》 页码 612-624 doi: 10.1007/s42524-023-0269-x
关键词: investment efficiency government investment air pollution control three-stage DEA-Malmquist model
《环境科学与工程前沿(英文)》 2023年 第17卷 第9期 doi: 10.1007/s11783-023-1716-y
● A systematic framework was developed to identify i-PPCPs for landfill leachate.
关键词: Landfill leachates PPCPs Indicator Screening criteria Source-specificity
Amin MANOUCHEHRIAN, Mohammad Fatehi MARJI, Mohsen MOHEBBI
《结构与土木工程前沿(英文)》 2012年 第6卷 第4期 页码 385-392 doi: 10.1007/s11709-012-0173-7
关键词: indirect boundary element method finite element method displacement tunnel case study
《结构与土木工程前沿(英文)》 2022年 第16卷 第2期 页码 202-213 doi: 10.1007/s11709-021-0795-8
关键词: excavated soil construction sludge geotechnical and underground engineering production classification
Pavement sustainability index for highway infrastructures: A case study of Maryland
Stella O. OBAZEE-IGBINEDION, Oludare OWOLABI
《结构与土木工程前沿(英文)》 2018年 第12卷 第2期 页码 192-200 doi: 10.1007/s11709-017-0413-y
关键词: pavement indices sustainability pavement performance flexible pavements
Wei ZENG, Jinwen ZHANG, Hongwei WANG, Hongtao ZHOU
《工程管理前沿(英文)》 2018年 第5卷 第1期 页码 88-97 doi: 10.15302/J-FEM-2018077
关键词: infrastructure mega-project supplier development critical success factors incentives case study
《工程管理前沿(英文)》 页码 563-576 doi: 10.1007/s42524-022-0198-0
关键词: Internet hospitals physicians’ online counseling online reputation offline reputation
标题 作者 时间 类型 操作
U-shaped association between telomere length and esophageal squamous cell carcinoma risk: a case-controlstudy in Chinese population
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期刊论文
Cyclooxygenase-2 gene-1195G/A genotype is associated with the risk of HBV-induced HCC: A case-controlstudy in Han Chinese people
Li-Feng LIU MD, PhD, Qiong CHEN MD, PhD, Ying CHANG MD, PhD, Ju-Sheng LIN MD, PhD, Jin-Liang ZHANG MM,
期刊论文
Identification of variants associated with sporadic thoracic aortic dissection: a case--control study
期刊论文
Alcohol and tea consumption in relation to the risk of nasopharyngeal carcinoma in Guangdong, China
Hong-Lian RUAN, Feng-Hua XU, Wen-Sheng LIU, Qi-Sheng FENG, Li-Zhen CHEN, Yi-Xin ZENG, Wei-Hua JIA,
期刊论文
FULL TIME-SPACE GOVERNANCE STRATEGY AND TECHNOLOGY FOR CROPLAND NON-POINT POLLUTION CONTROL IN CHINA
期刊论文
Efficiency evaluation of government investment for air pollution control in city clusters: A case from
期刊论文
Screening of indicator pharmaceuticals and personal care products in landfill leachates: a case study
期刊论文
Comparison of indirect boundary element and finite element methods A case study: Shiraz-Esfahan railway
Amin MANOUCHEHRIAN, Mohammad Fatehi MARJI, Mohsen MOHEBBI
期刊论文
Classification and quantification of excavated soil and construction sludge: A case study in Wenzhou,
期刊论文
Pavement sustainability index for highway infrastructures: A case study of Maryland
Stella O. OBAZEE-IGBINEDION, Oludare OWOLABI
期刊论文
Supplier development and its incentives in infrastructure mega-projects: A case study on Hong Kong-Zhuhai-Macao
Wei ZENG, Jinwen ZHANG, Hongwei WANG, Hongtao ZHOU
期刊论文